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Scientific Program
 

Tuesday, October 15, 2019

2:00-5:00 pm

Registration open

5:00-7:00 pm

Welcome reception

Wednesday, October 16, 2019

7:00-8:00 am

Registration open

8:00-8:45 am

Opening Ceremony

  • Welcome
  • Representative from Ministry of Health
  • Representative from Vietnam National University

8:45-9:15 am

KEYNOTE (Simultaneous Vietnamese translation)

Joost Wiersinga, University of Amsterdam, the Netherlands

What can the melioidosis community learn from the sepsis field?

9:15-9:45 am

Break

9:45-12:00 am

CLINICAL ASPECTS SESSION (Simultaneous Vietnamese translation)

Chairs: David Dance and Do Duy Cuong

Invited speakers:

(20 min each)

 

 

 

 

 

 

 

Selected presentations:

(10 min each)

Bart Currie, Menzies School of Health Research, Darwin, Australia

Melioidosis and the accidental opportunist

 

Susie Dunachie, Oxford University, UK

Diabetes and melioidosis:  what is the interaction, and what can we do?

 

Sotharith Bory, Calmette Hospital, Phnom Penh, Cambodia

Melioidosisand tuber culosis: the great mimicker

 

Jelmer Savelkoel , University of Amsterdam, the Netherlands

Melioidosis in travelers: an analysis of Dutch Melioidosis Registry data 1985-2018

 

Thong Phe, Sihanouk Hospital Center of HOPE, Cambodia

Epidemiology, clinical characteristics, outcome and factors influencing mortality of melioidosis in a Cambodian referral hospital: a 12-year retrospective study

 

Pham Thai Son, Children’s Hospital 2, Ho Chi Minh city, Vietnam

Characteristics of recently detected paediatric melioidosis in Southern Vietnam

 

Tonnii Sia, Sarawak General Hospital, Kuching, Sarawak, Malaysia

Pulmonary melioidosis in Malaysian Borneo - a single centre experience

12:00-1:15 pm

Lunch

1:15-2:45 pm

DIAGNOSTICS SESSION (Simultaneous Vietnamese translation)

Chairs: Vanaporn Wuthiekanun and Nguyen Vu Trung

Invited speaker:

(20 min)

 
 

Selected presentations:

(10 min each)

Narisara Chantratita, Mahidol University, Thailand

Identification of diagnostic markers for melioidosis by understanding the host response and bacterial exposure

 

P. Keim, Northern Arizona University, USA

BurkPx: a multiplex serodiagnostic bead assay to monitor Burkholderia pseudomalleiexposures in non-human primates

 

Laurel T. Jenkins , Centers for Disease Control and Prevention, Atlanta, USA

Evaluation of Burkholderia species inactivation procedures

 

Mary N. Burtnick, University of Nevada, Reno School of Medicine, Reno, NV, USA

Identification of Burkholderia cepacia strains that express a Burkholderia pseudomallei-like capsular polysaccharide

 

Ian Gassiep, Townsville Hospital, Townsville, Australia

Identification of Burkholderia pseudomallei using the VITEK mass spectrometer

2:45-3:15 pm

Break

3:15-4:15pm

Flash talks 1 (1 slide)

Poster presentation 1

4:15-6:15 pm

ANTIBIOTIC TREATMENT AND RESISTANCE SESSION (Simultaneous Vietnamese translation) Chairs: Bart Currie and Wirongrong Chierakul

Invited speaker:

(20 min)

 
 

Selected presentations:

(10 min each)

Herbert Schweizer, University of Florida , USA

Antibiotic resistance in Burkholderia pseudomallei: implications for melioidosis therapy

 

Derek S. Sarovich, University of the Sunshine Coast, Sippy Downs, Queensland, Australia

Comprehensive antimicrobial resistance detection from over 1,000 Burkholderia pseudomallei genomes

 

Carina M. Hall, Northern Arizona University, USA

Intrinsic and acquired antibiotic resistance in clinically relevant antibiotics - Which antibiotics rise to the top for melioidosis treatment?

 

Riccardo V. D’Elia, DSTL Porton Down, Salisbury, UK

Increased efficacy of antibiotic treatment for melioidosis using a vesicular oral delivery system

 

Michelle Nelson, DSTL Porton Down, Salisbury, UK

Efficacy of co-trimoxazole against melioidosis acquired by different routes of infection

 

Kay B. Barnes, DSTL Porton Down, Salisbury, UK

Investigating bacterial emergence following antibiotic treatment of a murine model of melioidosis

 

Courtney M. Sullivan, University of Western Australia, Australia

Targeting Ara4N synthesis in Burkholderia pseudomallei

7:30-10.30 pm

Conference Dinner and

 

HISTORY SESSION (Simultaneous Vietnamese translation)

Chairs: Trinh Thanh Trung and Ivo Steinmetz

Invited speakers:

David Dance, Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Laos

Whitmore and Krishnaswami revisited

 

Enoka Corea, University of Colombo, Sri Lanka

Lucius Nicholls - a man for all seasons

Thursday, October 17, 2019

7:30-8:30 am

Registration open

8:30-10:15 am

EPIDEMIOLOGY SESSION  I

Chairs: Ya-Lei Chen and Paul Keim

Invited speaker:

(20 min)

 

Selected presentations:

(10 min each)

Direk Limmathurotsakul, Mahidol University, Thailand

Update on epidemiology of melioidosis

 

Harjeet Virk , University of Amsterdam, the Netherlands

Global burden of melioidosis, 2015: a systematic review and data synthesis

 

Mindy Glass Elrod, Centers for Disease Control and Prevention, Atlanta, USA

Update on melioidosis in the Americas

 

Jedsada Kaewrakmuk, Chiang Mai University, Chiang Mai, Thailand

Molecular epidemiology of melioidosis in southern Thailand

 

Erez Bar-Haim, Israel Institute for Biological Research, Ness-Ziona, Israel

Characterization of a rare clinical isolate of Burkholderia pseudomallei associated with recreational traveling from India to Israel

 

Rachel Ximenes Ribeiro Lima, Universidade de Fortaleza - Unifor, Ceará, Brazil

Melioidosis in children and teenagers in Ceará: a case series in 16 years

 

Enoka M. Corea, University of Colombo, Sri Lanka

Unearthing a subterranean infection: the Sri Lankan experience

10:15-10:45 am

Break

10:45 am-12:15 pm

PATHOGENESIS SESSION

Chairs: Joost Wiersinga and David DeShazer

Invited speaker:

(20 min)

 
 

Selected presentations:

(10 min each)

Gan Yunn Hwen, National University of Singapore, Singapore

What is the consequence of Burkholderia induced host cell fusion for the bacteria and the host?

 

Nicole M. Bzdyl, University of Western Australia, Perth, WA, Australia

Peptidyl-prolyl isomerase, ppiB, is essential for proteome homeostasis and virulence in Burkholderia pseudomallei

 

Jessica R. Webb, Menzies School of Health Research, Darwin, Australia

Burkholderia pseudomalleilipopolysaccharide genotypes: clinical and geographical associations of >1,300 strains from the tropical “Top End” of the Northern Territory, Australia

 

Sarunporn Tandhavanant, Mahidol University, Thailand

Hemolysin co-regulated protein 1 (Hcp1) variant is associated with decreased virulence and low antigenicity in Burkholderia pseudomallei

 

Christopher Jenkins, DSTL Porton Down, Salisbury, UK

Investigating KdsD, an enzyme involved in the synthesis of the core region of LPS, in Burkholderia pseudomallei

 

Javier I. Sanchez-Villamil, University of Texas Medical Branch, USA

Modelling Burkholderia pseudomallei as a gastrointestinal pathogen and in vitro and in vivo testing to identify intestinal-specific virulence factors

12:15-1:15pm

Lunch

   

1:15-3:00 pm

EPIDEMIOLOGY SESSION  II

Chairs: Direk Limmathurotsakul and Harjett Virk

Invited speaker:

(20 min)

 

Selected presentations:

(10 min each)

Ya-Lei Chen, National Kaohsiung Normal University, Kaohsiung, Taiwan

Transmission modes of melioidosis in Taiwan

 

Ella Meumann, Menzies School of Health Research, Darwin, Australia

Clinical features and epidemiology of the emergent Asian Burkholderia pseudomallei sequence type 562 in northern Australia

 

Johanna S. Salzer, Centers for Disease Control and Prevention, Atlanta, USA

Case report and investigation of melioidosis in a resident of Texas, USA

 

ManophabLuangraj, Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Laos

The epidemiology and clinical features of melioidosis in Lao PDR: a 17-year prospective hospital based study

 

Chiranjay Mukhopadhyay, Manipal Academy of Higher Education, Manipal, India

Exploring melioidosis in India for last 30 years

 

Timothy J. J. Inglis, PathWest Laboratory Medicine Western Australia, Australia

Machine learning applications for melioidosis epidemiology in Sri Lanka

 

Jessica R. Webb, Menzies School of Health Research, Darwin, Australia

Epidemiological tracking of human melioidosis cases back to the environmental source using MLST and whole-genome sequencing: a 30-year summary of melioidosis source tracing in the Northern Territory, Australia

 

3:00-4:00 pm

VETERINARY ASPECTS SESSION

Chairs: Narisara Chantratita and Natkunam Ketheesan

Invited speaker:

(20min)

 

Selected presentations:

(10 min each)

Apichai Tuanyok, University of Florida , USA

Melioidosis in intensive pig farming system in southern Thailand

 

Audrey Rachlin, Menzies School of Health Research, Darwin, Australia

Melioidosis in captive slender-tailed meerkats (Suricatasuricatta) and hatchling saltwater crocodiles (Crocodylusporosus): Combining epidemiology, pathology and whole-genome sequencing to resolve two clusters of fatal B. pseudomallei infections at a Northern Australia Wildlife Park

 

Gabriel E. Wagner, Medical University of Graz, Graz, Austria

Glanderssero diagnostics: protein microarray guided development of a highly sensitive and specific lateral flow assay

4:00-4:30pm

Break

04:30-5:30pm

Flash talks 2 (1 slide)

Poster presentation 2

5:30-7:15 pm

IMMUNE RESPONSE SESSION

Chairs: Susie Dunachie and Eoin West

Invited Speaker:

(20 min)

 

Selected presentations:

(10 min each)

Danniel Altmann, Imperial College London, UK

Immunity to Burkholderia - what do we know and what do we urgently need to know?

 

Apinya Pumpuang, Mahidol University, Thailand

Distinct classes and subclasses of antibodies to hemolysin co-regulated protein 1 and O-polysaccharide and correlation with clinical characteristics of melioidosis patients

Panjaporn Chaichana, Mahidol University, Thailand

Identification of protective antibody profiles for vaccine development against melioidosis

 

Barbara Kronsteiner-Dobramysl, Oxford University, UK

Altered T cell metabolism, fuel utilization and metabolome is associated with diabetes status in Thai melioidosis patients and endemic controls

 

Patpong Rongkard, Oxford University, UK

Altered transcriptomic profiles in melioidosis patients with type 2 diabetes

 

Taniya Kaewarpai , Mahidol University, Thailand

Longitudinal immunoprofiling of plasma cytokines predicts outcomes in melioidosis

 

Jonathan Warawa, University of Louisville, USA

IL-12 microparticle therapeutic to respiratory melioidosis

 

Friday, October 18, 2019

8:00-8:30 am

Registration open

8:30-10:15 am

ENVIRONMENTAL ASPECTS SESSION

Chairs: Mark Mayo and David Dance

Invited Speaker:

(20 min)

 

Selected presentations:

(10 min each)

Mirjam Kaestli, Menzies School of Health Research, Australia

Burkholderia pseudomallei in the environment - we have only scratched the surface

 

Sheila Nathan, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia

Mapping the Burkholderia pseudomallei transcriptional landscape under conditions that mimic the environmental and clinical niche

 

Abdul Karim Russ Hassan, Universiti Kuala Lumpur Royal College of Medicine Perak, Malaysia

From laboratory based methods to deployable molecular detection of Burkholderia pseudomallei in the environmental settings in Malaysia

 

David M. Wagner, Northern Arizona University, Flagstaff, USA

Burkholderia pseudomallei is rare but ecologically established in Puerto Rico and the US Virgin Islands

 

Tushar Shaw, Manipal Academy of Higher Education, Manipal, India

Determining the influence of environmental factors on the presence of B. pseudomallei in the Indian soil

 

Khemngeun Pongmala, Université Paul Sabatier, Toulouse, France

Occurrence of Burkholderia pseudomallei along a 3 m deep soil profile in a paddy field of central Laos

 

Karoline Assig, Medical University of Graz, Graz, Austria

Getting closer to the environmental burden of Burkholderia pseudomallei: A new erythritol-based enrichment method improves cultural isolation of B. pseudomallei from rice paddy soils

10:15-10:45 am

Break

   

10:45 am-12:00pm

GENOMICS, PROTEOMICS AND METABOLOMICS SESSION

Chairs: Paul Keim and Sheila Nathan

Invited speaker:

(20 min)

 
 

Selected presentations:

(10 min each)

Claire Chewapreecha, Mahidol-Oxford Tropical Medicine Research Unit (MORU), Thailand

Genome-wide epistasis analyses identify genetic factors underlying Burkholderia pseudomallei survival in hostile environments

 

Lindsey K. Schmidt, University of Nevada, Reno School of Medicine, Reno, NV, USA

Use of bacterial cell surface labeling to identify new melioidosis vaccine candidates

 

David DeShazer, US Army Medical Research Institute of Infectious Diseases, Maryland, USA

Genetic, structural and functional characterization of novel, cryptic metabolites in Burkholderia thailandensis with potent antibiotic activity

 

Heather P. McLaughlin, Centers for Disease Control and Prevention, Atlanta, USA

In silico analyses of penicillin binding proteins in Burkholderia pseudomallei uncovers SNPs with utility for phylogeography and species differentiation

12:00-1:15pm

Lunch

1:15-3:00 pm

VACCINES AND PREVENTION SESSION

Chairs: Jo Prior and Paul Brett

Invited speaker:

(20 min)

 

Selected presentations:

(10 min each)

Alfredo Torres, University of Texas Medical Branch, USA

Defining correlates of protection of an effective melioidosis vaccine

 

Daniel Tapia, University of Texas Medical Branch, USA

Nanovaccines as highly immunogenic and protective therapy against inhalational Burkholderia pseudomallei infection

 

Paul J. Brett, University of Nevada, Reno School of Medicine, Reno, NV, USA

Subunit vaccines provide robust protection against a high dose challenge of Burkholderia pseudomallei

 

Taylor, A. W., DSTL Porton Down, UK

Targeting intracellular Burkholderia with monoclonal antibodies

 

Prior, J.L., DSTL Porton Down, UK

Novel anti-microbial therapies for melioidosis

 

Nittaya Khakhum, University of Texas Medical Branch, USA

Evaluation of Burkholderia pseudomalleitonBhcp1 live attenuated vaccine strain against aerosolized melioidosis infection

 

Caitlyn E. Orne, University of Nevada, Reno School of Medicine, Reno, NV, USA

Development of novel melioidosis vaccines using site-specific, single-point attachment of CPS to carrier proteins

3:00-3:30pm

Break

3:30pm

Concluding Remarks

 

Announcement of WMC 2022